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Read the Study - PMC10215789 Protects Mitochondria & Supports Cellular Energy Production Improves Adenosine Triphosphate (ATP) output and reduces oxidative mitochondrial damage Mitochondria generate ATP, the energy currency of the cell, but are also the primary source of reactive oxygen species (ROS)

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Following 24 h incubation, medium was removed to waste, and cells were treated with metformin (1, 2.5 or 10 mM) or vehicle control (H 2 O) diluted in cRPMI

Also nasal spray devices are typically 12.0 units per spray (125uL) The solution to get that into 4 sprays containing 20mg per spray (1 dose) = 80mg delivered would be a 16% concentration